abstract：:Parkinson's disease (PD) is one of the most common neurodegenerative diseases. Identifying PD cognitive impairment (PDCI) in the early stage will help slow or prevent PD dementia. Susceptibility loci for PDCI are inconsistent in different studies. The aim of this study is to determine susceptibility loci for PDCI in t...

journal_title：Neuroscience letters

authors： Liu HJ,Li XY,Chen H,Yu HL,Tao QQ,Wu ZY

更新日期：2020-06-21 00:00:00

abstract：:Parkinson's disease (PD) is a chronic and progressive neurodegenerative disorder. Epidemiological studies suggest that the exposure of the herbicide glyphosate may influence the development of PD in humans. In this study, we examined whether the exposure of glyphosate can affect the reduction of dopamine transporter (...

journal_title：Neuroscience letters

authors： Pu Y,Chang L,Qu Y,Wang S,Tan Y,Wang X,Zhang J,Hashimoto K

更新日期：2020-06-21 00:00:00

abstract：:For the first time, a review article focuses exclusively on the role of the protein kinase CK2 in mono- and poly-nucleated mammalian skeletal muscle cells. While CK2, a pleiotropic serine/threonine kinase was originally thought to phosphorylate mainly casein, later evidence found glycogen phosphorylase and glycogen sy...

journal_title：Neuroscience letters

authors： Hashemolhosseini S

更新日期：2020-06-11 00:00:00

abstract：:In addition to providing structural, metabolic and trophic support to neurons, glial cells of the central, peripheral and enteric nervous systems (CNS, PNS, ENS) respond to and regulate neural activity. One of the most well characterized features of this response is an increase of intracellular calcium. Astrocytes at ...

journal_title：Neuroscience letters

authors： Heredia DJ,De Angeli C,Fedi C,Gould TW

更新日期：2020-06-11 00:00:00

abstract：:The human hypothalamus is at the center of the human limbic system anatomically and physiologically. The hypothalamus plays pivotal roles in controlling autonomic responses and instinctive behaviors such as regulating fear, aggression, learning, feeding behavior, circadian rhythm, and reproductive activities. The deta...

journal_title：Neuroscience letters

authors： Kamali A,Ghazi Sherbaf F,Rahmani F,Khayat-Khoei M,Aein A,Gandhi A,Shah EG,Sair HI,Riascos RF,Esquenazi Y,Zhu JJ,Keser Z,Hasan KM

更新日期：2020-05-29 00:00:00

abstract：:Recently, there has been a lot of interest in the neuroimaging community in exploring fMRI time-series measures of local neuronal activity and excitation/inhibition (E/I) balance in the brain. In this preliminary study we probed the sensitivity of widely used sample entropy (SE) measure at multiple scales to controlle...

journal_title：Neuroscience letters

authors： Maltbie EA,Howell LH,Sun PZ,Miller R,Gopinath KS

更新日期：2020-05-29 00:00:00

abstract：:The aim of the study was to investigate the characteristics of the oscillatory dynamics of brain activity during the perception of negative, positive, and neutral sentences in healthy individuals with differing severity of depressive symptoms at the preclinical stage. The study involved 34 healthy people (22 women). T...

journal_title：Neuroscience letters

authors： Bocharov AV,Savostyanov AN,Tamozhnikov SS,Merkulova EA,Saprigyn AE,Proshina EA,Knyazev GG

更新日期：2020-05-29 00:00:00

abstract：:Accumulating evidences have pointed out that neuroinflammation is involved in Parkinson's disease (PD) pathogenesis. Toll-like receptor 3 (TLR3), as a member of pattern-recognition receptors (PRRs), is known to play a pivotal role in inflammatory responses and immune responses. It was recently suggested that TLR3 was ...

journal_title：Neuroscience letters

authors： Wang J,Liu Y,Liu Y,Zhu K,Xie A

更新日期：2020-05-29 00:00:00

abstract：BACKGROUND:Gabor patterns are defined as the product of a sinusoid function and a Gaussian envelope and are commonly used in visual and attentional research due to their ability to selectively stimulate the primary visual cortex. The aim of this study was to investigate whether Gabor patterns can be used as visual stim...

journal_title：Neuroscience letters

authors： Caballero-Puntiverio M,Prichardt S,Klem L,Bundesen C,Vangkilde S,Andreasen JT

更新日期：2020-05-29 00:00:00

abstract：:Deep brain stimulation (DBS) is associated with substantial improvements in motor symptoms of PD. Emerging evidence has suggested that nonlinear measures of complexity may provide greater insight into the efficacy of anti-PD treatments. This study investigated sample entropy and complexity index values in individuals ...

journal_title：Neuroscience letters

authors： Powell DW,Blackmore SE,Puppa M,Lester D,Murray NG,Reed-Jones RJ,Xia RP

更新日期：2020-05-29 00:00:00

abstract：:Antipsychotic drugs remain the mainstay of pharmacotherapy for schizophrenia. As there are large individual variations in efficacy and side-effects of antipsychotic drugs, there is a strong demand for personalized medication to treat schizophrenia. Pharmacogenetic research into antipsychotic drugs has examined a numbe...

journal_title：Neuroscience letters

authors： Han M,Deng C

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Studies have demonstrated that the failure of oligodendrocyte precursor cells (OPCs) differentiation as a major cause of remyelination failure in demyelinating disease. The reasons for this failure are not completely understood. We hypothesized that the present of myelin debris in CNS play an important role ...

journal_title：Neuroscience letters

authors： Liu Q,Lv HW,Yang S,He YQ,Ma QR,Liu J

更新日期：2020-04-23 00:00:00

abstract：:The Heat Shock Factors (HSFs) have been historically identified as a family of transcription factors that are activated and work in a stress-responsive manner, after exposure to a large variety of stimuli. However, they are also critical in normal conditions, in a life long manner, in a number of physiological process...

journal_title：Neuroscience letters

authors： Duchateau A,de Thonel A,El Fatimy R,Dubreuil V,Mezger V

更新日期：2020-04-23 00:00:00

abstract：:Genetic factors play an important role in Parkinson's disease (PD) and vary from different races. A previous genome-wide association study (GWAS) identified 17 novel risk loci that were associated with PD in Caucasians. Several subsequent studies investigated the association between these loci and PD in Chinese popula...

journal_title：Neuroscience letters

authors： Hu X,Mao C,Hu Z,Zhang Z,Zhang S,Yang Z,Fan Y,Fan L,Zheng H,Yang J,Liu Y,Yuan Y,Wang Y,Shi C,Xu Y

更新日期：2020-04-23 00:00:00

abstract：:The dopaminergic system has a long history of being associated with reward-related activities but the developmental consequences of blocking dopamine receptor function on reward-based associative learning has been less studied. To this end, male, Long Evans rats were systemically (i.p.) treated with the dopamine recep...

journal_title：Neuroscience letters

authors： Holahan MR,Goheen K

更新日期：2020-04-23 00:00:00

abstract：:Inattention and impulsivity are the two most important indices for evaluations of ADHD. Currently, inattention and impulsivity were evaluated by clinical scales. The intelligent evaluation of the two indices using machine learning remains largely unexplored. This paper aimed to build regression modes for inattention a...

journal_title：Neuroscience letters

authors： Wang XH,Xu J,Li L

更新日期：2020-04-17 00:00:00

abstract：:Spinal cord injury (SCI) triggers pronounced inflammatory responses that are accompanied by neuronal disruption and functional deficits. SCI treatment remains an unmet clinical need. Emerging evidence suggests that riluzole may exert a neuroprotective effect due to its anti-inflammatory properties. However, details of...

journal_title：Neuroscience letters

authors： Wu Q,Zhang Y,Zhang Y,Zhang W,Zhang W,Liu Y,Xu S,Guan Y,Chen X

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Brain function relies on the capacity of neurons to locally modulate each other at the level of synapses. Therefore, the exosomal pathway may constitute a well-designed mechanism for local and systemic interneuronal transfer of information within functional brain networks. Exosomes bind to and are endocytose...

journal_title：Neuroscience letters

authors： Yu X,Abdul M,Fan BQ,Zhang L,Lin X,Wu Y,Fu H,Lin Q,Meng H

更新日期：2020-04-01 00:00:00

abstract：:The terpene lactones of Ginkgo biloba extract, namely ginkgolides (A, B, and C) and bilobalide, possess antioxidant, anti-inflammatory, and neuroprotective effects. They are widely prescribed for the treatment of cerebral dysfunctions and neurological impairments. In addition, they demonstrate antagonistic action at t...

journal_title：Neuroscience letters

authors： Nishimon S,Yamaguchi M,Muraki H,Sakai N,Nishino S

更新日期：2020-03-23 00:00:00

abstract：:This study deals with the coordination of bilateral synchronous and asynchronous hand movements. Cooperative hand movements (e.g. opening a bottle) were shown to be coordinated by a neural coupling, reflected in the appearance of reflex responses in forearm muscles of both sides to unilateral arm nerve stimulation. Th...

journal_title：Neuroscience letters

authors： Köchli S,Scharfenberger T,Dietz V

更新日期：2020-02-16 00:00:00

abstract：:Our previous investigations revealed that progranulin (PGRN) is a lysosomal protein involved in hippocampal neurogenesis and neuroinflammation. However, the possible involvement of PGRN in regulating inflammatory response and mediating neuronal activity is still not well-defined. Here, we demonstrate that PGRN deficie...

journal_title：Neuroscience letters

authors： Bai D,Ma Y,Lv L,Wang Y,Yang W,Ma Y

更新日期：2020-02-16 00:00:00

abstract：:Aphasia is a highly disabling language disorder usually caused by a left stroke brain damage. Even if traditional language therapies have been proved to induce an adequate clinical recovery, a large percentage of patients are left with chronic deficits at 6 months post-stroke. Therefore, new strategies to common speec...

journal_title：Neuroscience letters

authors： Marangolo P

更新日期：2020-02-06 00:00:00

abstract：:Aggression reflects the psychological and physical behavior that perpetrator intends to harm victim. Initiation of aggression is influenced by the distal factors (e.g. personality) and proximate causes (e.g. affect) of perpetrator. However, few studies explored the brain structural basis of relationship between these ...

journal_title：Neuroscience letters

authors： Zhu X,Wang K,Cao A,Zhang Y,Qiu J

更新日期：2020-01-23 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disease characterized by a progressive loss of memory and cognitive decline. Over the last decade, it has been found that defects in sensory systems could be highly associated with AD. Hearing is an important neural sense. However, little is known about hearing functiona...

journal_title：Neuroscience letters

authors： Liu Y,Fang S,Liu LM,Zhu Y,Li CR,Chen K,Zhao HB

更新日期：2020-01-19 00:00:00

abstract：:Research indicates that threat-induced changes in standing balance are associated with shifts in attention focus. This study investigated whether distracting attention modifies threat-induced changes in standing balance. Twenty-five healthy young adults stood without (No Threat) and with (Threat) the possibility of re...

journal_title：Neuroscience letters

authors： Johnson KJ,Watson AM,Tokuno CD,Carpenter MG,Adkin AL

更新日期：2020-01-18 00:00:00

abstract：:Amyotrophic Lateral Sclerosis (ALS) is a devastating and fatal neurodegenerative disease affecting approximately 30,000 individuals in the United States. The average age of onset is 55 years and progression of the disease is rapid with most patients dying of respiratory failure within 3-5 years. Currently available th...

journal_title：Neuroscience letters

authors： St Martin JL,Wang L,Kaprielian Z

更新日期：2020-01-18 00:00:00

abstract：:Opioids are used in clinical practice to relieve moderate to severe pain. Prolonged use of opioids can lead to a situation of analgesic tolerance and dependence. Several mechanisms are involved in the tolerance to analgesic opioids, including desensitization or internalization of the opioid receptor, elevation of cAMP...

journal_title：Neuroscience letters

authors： Shirooie S,Esmaeili J,Sureda A,Esmaeili N,Mirzaee Saffari P,Yousefi-Manesh H,Dehpour AR

更新日期：2020-01-18 00:00:00

abstract：:Epileptic seizures are frequent in patients with glioma, and anticonvulsive treatment is often indicated. Glioma cells release glutamate via the Xc- antiporter system, which appears to be a major pathomechanism of glioma-associated seizures and excitotoxicity. In addition, the proliferation and survival of the tumor c...

journal_title：Neuroscience letters

authors： Mayer J,Kirschstein T,Resch T,Porath K,Krause BJ,Köhling R,Lange F

更新日期：2020-01-10 00:00:00

abstract：:Super-resolution microscopy techniques offer subdiffraction limited resolution that is two- to ten-fold improved compared to that offered by conventional confocal microscopy. This breakthrough in resolution for light microscopy has contributed to new findings in neuroscience and synapse biology. This review will focus...

journal_title：Neuroscience letters

authors： Badawi Y,Nishimune H

更新日期：2020-01-10 00:00:00

abstract：:Online shopping festivals play a significant role in consumers' purchase decision and have been the focus of much research and many marketing practices. However, research has yet to explore which product categories can promote consumer purchase intention during online shopping festivals. This study carried out a neuro...

journal_title：Neuroscience letters

authors： Shang Q,Jin J,Qiu J

更新日期：2020-01-10 00:00:00

abstract：:This study evaluated the immediate and persistent behavioral and molecular consequences (i.e., emotional signs emerging during withdrawal and signs of neurotoxicity) following adolescent morphine exposure with a sex perspective. Basally, and prior to drug treatment, adolescent female rats showed smaller body weight an...

journal_title：Neuroscience letters

authors： Jiménez-Romero F,Bis-Humbert C,García-Fuster MJ

更新日期：2020-01-10 00:00:00

abstract：:Chronic demyelination and the concomitant loss of trophic support and increased energy demands in axons are thought to contribute to neurodegeneration in a number of neurological diseases such as multiple sclerosis (MS). Adult oligodendrocyte precursor cells (OPCs) play an important role in these demyelinating disease...

journal_title：Neuroscience letters

authors： Harrington EP,Bergles DE,Calabresi PA

更新日期：2020-01-10 00:00:00

abstract：:Periostin has dual roles as a multifunctional cytokine and an extracellular matrix protein that binds to several integrins on a variety of cells. This study evaluated whether the expression and cellular localization of periostin changes in the spinal cord of mice with experimental autoimmune encephalomyelitis (EAE), a...

journal_title：Neuroscience letters

authors： Choi Y,Kim J,Ahn M,Shin T

更新日期：2020-01-10 00:00:00

abstract：:Physical exercise-induced inflammation may be beneficial when exercise is regular but it may be harmful when exercise is intense and performed by unaccustomed individuals/rats. Molecular hydrogen (H2) has recently emerged as a powerful anti-inflammatory, antioxidant and anti-apoptotic molecule in a number of pathologi...

journal_title：Neuroscience letters

authors： Nogueira JE,de Deus JL,Amorim MR,Batalhão ME,Leão RM,Carnio EC,Branco LGS

更新日期：2020-01-10 00:00:00

abstract：:Down syndrome is the most common genetic cause of intellectual disability and occurs due to the trisomy of human chromosome 21. Adolescent and adult brains from humans with Down syndrome exhibit various neurological phenotypes including a reduction in the size of the corpus callosum, hippocampal commissure and anterio...

journal_title：Neuroscience letters

authors： Jain S,Watts CA,Chung WCJ,Welshhans K

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:Exploring the impact of glucocerebrosidase gene (GBA) polymorphisms and mutations on the pathogenesis of Parkinson's disease dementia (PDD) plays an important role in the diagnosis and treatment of this disease. This meta-analysis aimed to investigate the effects of GBA polymorphisms and mutations on the risk...

journal_title：Neuroscience letters

authors： Zhang Y,Chen J,Xu C,Feng J,Li J

更新日期：2020-01-01 00:00:00

abstract：:Gastrin releasing peptide (GRP) is involved in the stimulation of gastric acid release from the stomach. It also mediates effects on feeding behavior. It is associated with anorexigenic effects in both mammalian and avian species, but the mechanism of action is unknown in any species. The aim of the present study was ...

journal_title：Neuroscience letters

authors： Bohler M,Dougherty C,Tachibana T,Gilbert ER,Cline MA

更新日期：2019-11-20 00:00:00

abstract：:LPS-induced microglial activation has a major influence on neuronal damage in the inflammatory process. Integral to this is the cellular and molecular interaction between microglia and neurons. Exosomes, a mediator of communication between cells, can transfer lipids, proteins and nucleic acids, affecting many donor an...

journal_title：Neuroscience letters

authors： Chen X,Qian B,Kong X,Hao J,Ye Y,Yang K,Xu T,Zhang F

更新日期：2019-11-01 00:00:00

abstract：:Prefoldin is a molecular chaperone that assists the folding of newly synthesized polypeptide chains and prevents aggregation of misfolded proteins. Dysfunction of prefoldin is one of the causes of neurodegenerative diseases such as Alzheimer's disease. The aim of this study was to clarify the involvement of prefoldin ...

journal_title：Neuroscience letters

authors： Kadoyama K,Matsuura K,Takano M,Maekura K,Inoue Y,Matsuyama S

更新日期：2019-11-01 00:00:00

abstract：:Hypoxic-ischemic brain damage (HIBD) leads to acute death and chronic neurological dysfunction in neonates. To date, there is no satisfactory acknowledged strategy to provide neuroprotection completely. Verbascoside (VB) has been proved to possess antioxidative, anti aging and neuroprotective activities. The aim of th...

journal_title：Neuroscience letters

authors： Wei W,Lu M,Lan X,Liu N,Wang H,Du J,Sun T,Li Y,Yu J

更新日期：2019-10-15 00:00:00